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Living with moderate-to-severe atopic dermatitis – also known as eczema – can be challenging. In addition to having the physical burden that includes flare-ups of red, itchy, painful skin, there can also be a significant emotional and social impact.,,, But those living with eczema aren’t alone. Eczema is one of the most common chronic inflammatory skin diseases, impacting people of all genders, races, ethnicities and ages.,,, There’s no time like the present to learn more about moderate-to-severe eczema, and to myth bust four common misconceptions about this condition.
Myth: Most people grow out of their eczema
Eczema most often occurs in babies and children. While childhood eczema may go away or get better with age, about 50% of pediatric patients may have recurrent symptoms into adolescence and adulthood., In fact, there are about 6.6 million adults living with moderate-to-severe eczema in the U.S.
Myth: Eczema is “just a rash”
While eczema is often defined by itchy, dry, scaly or red skin, its reach extends beyond the surface of the skin. The physical burden of eczema can be relentless and demanding with a constant cycle of itching and scratching.,
A study of over 1,000 people showed that about 6 in 10 people struggle to control their moderate-to-severe eczema. It’s important to tell your doctor about your eczema signs and symptoms. This can help them suggest a treatment plan that’s right for you.
Myth: The cause of eczema is the same for everyone
Eczema occurs when inflammation of the skin and skin barrier defects change your skin's ability to hold moisture. This can make your skin dry and easily irritated., There are a number of things that can trigger eczema flares, including genetic, environmental and emotional factors.
For example, a child may be more likely to develop eczema if their parent has eczema, allergic rhinitis, asthma or food allergy. Some fabrics, food, sweat or even stress can also cause flares. Some research suggests that stress makes it harder for your skin to recover from damage caused by eczema. This extended healing time can then cause more stress — adding to a continuous cycle of stress and eczema.
Myth: Topical creams and ointments are the only options available to treat moderate-to-severe eczema
Although there is no cure for eczema, there are different treatment options available. Appropriate options depend on different factors, such as age, eczema severity and previous treatment history., While current therapeutic approaches do include applying over-the-counter moisturizers and emollients, or prescription topicals, there are also oral and injectable medications, and phototherapy. One option may be CIBINQO (abrocitinib) – a once-daily prescription pill to treat adults with moderate-to-severe eczema (atopic dermatitis) that did not respond to other treatment and is not well controlled with prescription medicines, including biologics, or when they cannot be tolerated. Learn more at www.CIBINQO.com.
If you've had success with CIBINQO, consider sharing your story to help inspire others at www.CIBINQO.com/share-your-experience. It can feel great to make a positive impact for others, especially those who may be struggling.
IMPORTANT SAFETY INFORMATION AND INDICATION FOR CIBINQO
CIBINQO may cause serious side effects, including:
Serious infections. CIBINQO can lower your immune system’s ability to fight infections. Do not start CIBINQO if you have any kind of infection unless your healthcare provider tells you it is okay. Serious infections, including tuberculosis (TB) and infections caused by bacteria, fungi, or viruses that can spread throughout the body, have occurred in people taking CIBINQO or other similar medicines. Some people have died from these infections. Your risk of developing shingles may increase while taking CIBINQO.
Your healthcare provider should test you for TB before treatment with CIBINQO and monitor you closely for signs and symptoms of TB infection during treatment.
Before and after starting CIBINQO, tell your doctor right away if you have an infection, are being treated for one, or have symptoms of an infection, including:
CIBINQO can make you more likely to get infections or worsen infections you have.
There is an increased risk of death in people 50 years and older who have at least one heart disease (cardiovascular) risk factor and are taking a Janus kinase (JAK) inhibitor (such as CIBINQO).
Cancer and immune system problems. CIBINQO may increase your risk of certain cancers by changing the way your immune system works. Lymphoma and other cancers, including skin cancers, can happen. People, especially current or past smokers, have a higher risk of certain cancers, including lymphoma and lung cancers, while taking a JAK inhibitor. Follow your healthcare provider’s advice about having your skin checked for skin cancer during treatment. Limit the amount of time you spend in sunlight and avoid using tanning beds or sunlamps. When in the sun, wear protective clothing and use SPF 30+ sunscreen. This is especially important if you have very fair skin or a family history of skin cancer. Tell your healthcare provider if you have ever had any type of cancer.
There is an increased risk of major cardiovascular (CV) events such as heart attack, stroke or death in people 50 years and older who have at least one heart disease (CV) risk factor and are taking a JAK inhibitor, especially for current or past smokers.
Some people taking CIBINQO have had major cardiovascular events.
Get emergency help right away if you develop any symptoms of a heart attack or stroke while taking CIBINQO, including:
Blood clots. Blood clots in the veins of your legs (deep vein thrombosis, DVT) or lungs (pulmonary embolism, PE) can happen in some people taking CIBINQO. This may be life-threatening. Blood clots in the veins of the legs and lungs have happened more often in people 50 years and older, with at least one heart disease (CV) risk factor, taking a JAK inhibitor. Tell your healthcare provider if you have had blood clots in the veins of your legs or lungs in the past.
Get medical help right away if you have any signs and symptoms of blood clots including swelling, pain, or tenderness in one or both legs; sudden, unexplained chest or upper back pain; shortness of breath or difficulty breathing.
Changes in certain laboratory test results. Your doctor should do blood tests before and during treatment with CIBINQO to check your lymphocyte, neutrophil, red blood cell, and platelet counts. You should not take CIBINQO if these counts are too low. Your healthcare provider may stop treatment for a period of time if there are changes in these blood test results. You may also have changes in other laboratory tests, such as your blood cholesterol levels. Your doctor should do blood tests about 4 weeks after you start treatment and 4 weeks after any increase in dose to check blood cell counts and as often as needed for other laboratory tests.
During the first 3 months of treatment with CIBINQO, do not take medicines that prevent blood clots except low-dose aspirin (=81 mg daily), if prescribed.
Before taking CIBINQO, tell your healthcare provider if you:
The most common side effects of CIBINQO include common cold, nausea, headache, herpes simplex including cold sores, increased blood level of creatinine phosphokinase, dizziness, urinary tract infection, tiredness, acne, vomiting, mouth and throat pain, flu, stomach flu, bacterial skin infection, high blood pressure, allergic skin rash to something you contacted, stomach pain, shingles, and low platelet count.
CIBINQO may cause fertility problems in females, which may affect the ability of females to get pregnant. Talk to your healthcare provider if you have concerns about fertility.
Separation or tear to the lining of the back part of the eye (retinal detachment) has happened in people treated with CIBINQO. Call your healthcare provider right away if you have any sudden changes in your vision.
These are not all of the possible side effects of CIBINQO.
What is CIBINQO (si-BINK-oh)?
CIBINQO (abrocitinib) is a prescription medicine to treat adults with moderate-to-severe eczema (atopic dermatitis) that did not respond to other treatment and is not well controlled with prescription medicines, including biologics, or when they cannot be tolerated.
It is not known if CIBINQO is safe and effective in children.
You are encouraged to report adverse events related to Pfizer products by calling 1-800-438-1985 (U.S. only). If you prefer, you may contact the U.S. Food and Drug Administration (FDA) directly. Visit www.fda.gov/MedWatch or call 1-800-FDA-1088.
CIBINQO is available in 50 mg, 100 mg, and 200 mg pills.
This article is sponsored by Pfizer Inc.
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